Quick Facts
- Category
- Cognitive
- Molecular Weight
- 773.9 Da
- Amino Acids
- 7
- Storage
- Store lyophilized at -20°C.
- Solubility
- Soluble in water
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Description
PE-22-28 is a synthetic heptapeptide with the sequence Gly-Val-Ser-Trp-Gly-Leu-Arg, corresponding to residues 22-28 of the sortilin propeptide (UniProt Q99523; sortilin is also designated neurotensin receptor 3, NTSR3). It is the shortened analogue of spadin, which spans residues 12-28 of the same propeptide. Molecular formula C35H55N11O9, molecular weight 773.9 Da. Research applications focus on TREK-1 potassium channel modulation and neuronal signaling.
Research Summary
PE-22-28 is a relatively novel peptide under investigation for neurotrophic properties. Preclinical studies suggest it may promote neuronal survival and enhance synaptic plasticity through modulation of TREK-1 potassium channels. Research is in early stages, primarily limited to in vitro and rodent models.
Mechanism of Action
Proposed to inhibit TREK-1 two-pore domain potassium channels, leading to increased neuronal excitability and enhanced neurotransmitter release. This mechanism parallels the action of spadin, a natural TREK-1 inhibitor linked to neurotrophic signaling.
Known Research Compound Interactions
Based on published preclinical research literature
For laboratory research reference only. Not for human consumption. Interaction data derived from preclinical studies and receptor binding profiles. Always consult primary literature for specific research protocols.
Interaction assessments based on receptor binding affinity, signaling pathway analysis, and published preclinical data. For laboratory research use only. Not for human consumption.
For laboratory research use only. Not for human consumption.