Quick Facts
- Category
- Specialty
- Molecular Weight
- 3326.8 Da (free acid; amidated 3325.85 Da)
- CAS Number
- 37221-79-7
- Amino Acids
- 28
- Storage
- Store lyophilized at -20°C. Reconstituted at 4°C for up to 7 days.
- Solubility
- Soluble in water and dilute acetic acid
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Description
Vasoactive Intestinal Peptide (VIP) is a 28 amino acid neuropeptide belonging to the glucagon/secretin superfamily. It functions as a neurotransmitter and neuromodulator, with broad distribution in the central and peripheral nervous systems. Research applications include studies of smooth muscle relaxation, vasodilation, and immune modulation.
Research Summary
VIP has been studied extensively in neuroscience and immunology research since its discovery in 1970. Research demonstrates roles in smooth muscle relaxation, vasodilation, pancreatic secretion regulation, and neuroprotection. Clinical investigations explore its potential in inflammatory conditions, pulmonary hypertension, and neurological disorders.
Mechanism of Action
Activates VPAC1 and VPAC2 G-protein coupled receptors, stimulating adenylyl cyclase and increasing intracellular cAMP levels. This triggers PKA-mediated phosphorylation cascades that regulate smooth muscle tone, secretion, and immune cell function. Also signals through PAC1 receptor at higher concentrations.
Known Research Compound Interactions
Based on published preclinical research literature
For laboratory research reference only. Not for human consumption. Interaction data derived from preclinical studies and receptor binding profiles. Always consult primary literature for specific research protocols.
Interaction assessments based on receptor binding affinity, signaling pathway analysis, and published preclinical data. For laboratory research use only. Not for human consumption.
For laboratory research use only. Not for human consumption.